Elements condensing into dust grains is an important physical process that occurs in the ISM. Through studies on extinction, scattering, heating and depletion of elements out of gas-phase, it has long been known that grains have a major effect on observed spectra of galaxies. Despite the large amount of observations available on extinction, scatter and heating, details of depletions onto grains and their effect on observed emission-line spectra are rarely studied. We explore the effects of grain depletions on strong spectral lines, and find non-trivial results. Our results suggest that the level of depletion, not only affects the emission line strength of corresponding ions, but also changes the abundance of coolants in the ISM gas, hence affecting its temperature. In addition, we include new code into Cloudy, allowing a user to alter the degree of grain depletions in a given model.