Matrix Stiffness: the Conductor of Organ Fibrosis.
| Author | |
|---|---|
| Abstract | :
Organ fibrosis is a lethal component of scleroderma. The hallmark of scleroderma fibrosis is extensive extracellular matrix (ECM) deposition by activated myofibroblasts, specialized hyper-contractile cells that promote ECM remodeling and matrix stiffening. The purpose of this review is to discuss novel mechanistic insight into myofibroblast activation in scleroderma. |
| Year of Publication | :
2018
|
| Journal | :
Current rheumatology reports
|
| Volume | :
20
|
| Issue | :
1
|
| Number of Pages | :
2
|
| Date Published | :
2018
|
| ISSN Number | :
1523-3774
|
| URL | :
https://dx.doi.org/10.1007/s11926-018-0710-z
|
| DOI | :
10.1007/s11926-018-0710-z
|
| Short Title | :
Curr Rheumatol Rep
|
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