Temperature sensitivity of two-pore (K2P) potassium channels.
| Author | |
|---|---|
| Abstract | :
At normal body temperature, the two-pore potassium channels TREK-1 (K2P2.1/KCNK2), TREK-2 (K2P10.1/KCNK10), and TRAAK (K2P4.1/KCNK2) regulate cellular excitability by providing voltage-independent leak of potassium. Heat dramatically potentiates K2P channel activity and further affects excitation. This review focuses on the current understanding of the physiological role of heat-activated K2P current, and discusses the molecular mechanism of temperature gating in TREK-1, TREK-2, and TRAAK. |
| Year of Publication | :
0
|
| Journal | :
Current topics in membranes
|
| Volume | :
74
|
| Number of Pages | :
113-33
|
| Date Published | :
2014
|
| ISSN Number | :
1063-5823
|
| URL | :
https://linkinghub.elsevier.com/retrieve/pii/B978-0-12-800181-3.00005-1
|
| DOI | :
10.1016/B978-0-12-800181-3.00005-1
|
| Short Title | :
Curr Top Membr
|
| Download citation |